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BOF 12
A 35-year-old female has had a right hemicolectomy and
ileal resection for Crohn’s disease. She presents with diarrhoea. Investigations
do not reveal recurrence of Crohn’s disease. A 75 SeHCAT scan shows
low values.
In this patient the diarrhoea is best managed by treating
with:
a)
Codeine phosphate
b)
Budesonide
c)
Loperamide
d)
Cholestyramine
e)
Azathioprine
Answer:
d)
Ileal resection causes bile acid malabsorption, which
results in diarrhoea because the unabsorbed bile acids have a secretory effect
on colonic epithelium. The 75 SeHCAT scan measures retention at 7
days of orally administered 75 Se labelled homocholic acid conjugated
with taurine. Low values indicate bile acid malabsorption (BAM). Treatment is
with bile acid sequestrants such as cholestyramine.
Last Updated: 19/02/06
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