Answer BOF 34

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BOF: 34

A 30-year-old male has been diagnosed as having pulmonary tuberculosis. He was started on a therapeutic regime that contains isoniazid. He has been tested and been found to be a fast acetylator. Which of the following may occur as a consequence of his acetylator status?

a)      Increased risk of drug resistance

b)      Increased risk of hepatotoxicity

c)      Increased risk of peripheral neuropathy

d)      Increased risk of megaloblastic anaemia

e)      Increased risk of convulsions

Answer

a)

Enzymatic acetylation of isoniazid by N-acetyl transferases reduces the therapeutic effectiveness of the drug. This results in chronic underdosing, which gives inadequate therapy and may give rise to the development of drug resistance.

Last Updated: 17/04/06

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