BOF: 23
A 35-year-old female presented with a history of lethargy
and jaundice. She also complained of joint pains and mild pain in the right
upper quadrant.
She did not drink and did not take any medications
including over the counter preparations or herbal remedies.
On examination the patient was not obese, she had mild
jaundice and the liver was enlarged 3 fingerbreadths below the costal margin and
was tender.
Investigations revealed normal haematology raised ALT, ALP
and bilirubin.
Gammaglobulin levels were raised and she was positive for
ANA and SMA antibodies.
She was negative for hepatitis B and C viruses and
screening for haemochromatosis, Wilson’s disease and alpha antitrypsin
deficiency was negative.
Ultrasound scanning did not reveal a focal lesion.
Liver biopsy was performed and this showed a
lymphoplasmacellular infiltrate in the portal tracts with necrosis affecting the
limiting plate.
In this patient:
a)
Selective elevation of Ig G antibody is typical
b)
Selective elevation of Ig A antibody is typical
c)
Selective elevation of Ig M antibody is typical
d)
Positive anti SMA is diagnostic of this condition
e)
Positive anti LKM antibody is diagnostic of this condition
