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Splenomegaly Enlargement of the spleen may be due to: §
Neoplastic Disorders Chronic myeloid leukaemia, polycythaemia rubra vera, chronic lymphocytic leukaemia, lymphoma, myeloma ©
Inflammatory Disorders Infectious mononucleosis, brucella, septicaemia, typhoid, tuberculosis, sarcoid, rheumatoid arthritis (Felty’s syndrome) ª Extramedullary Erythropoiesis Myelofibrosis, thalassaemia ¨ Hypertrophy Haemolytic anaemia (Hereditary spherocytosis), idiopathic thrombocytopaenic purpura § Congestion Malaria (acute phase in the chronic phase hyperplasia occurs) © Portal Hypertension Cirrhosis of the liver, portal vein thrombosis Hyposplenism Hyposplenism cannot be detected clinically. It may be caused by: ª Coeliac disease ¨ Sickle cell disease § Surgery Hepatosplenomegaly Hepatosplenomegaly may be due to: © Neoplastic Disorders Myeloproliferative disease (chronic myeloid leukaemia) Lymphoproliferative disease (lymphoma, chronic lymphocytic leukaemia) ª Inflammatory Disorders Cytomegalovirus, malaria, kala azar, tuberculosis, brucella, toxoplasmosis ¨ Extramedullary Erythropoiesis Extramedullary erythropoiesis occurs in: Myelofibrosis, thalassaemia § Venous Congestion Venous congestion occurs in: Malaria ©
Lysosomal Storage Diseases Lysosomal storage diseases are a
group of disorders caused by inherited deficiencies of individual enzymes within
lysosomes. Patients with Niemann-Pick disease, Gaucher disease have
hepatosplenomegaly. ª
Interstitial Infiltration Amyloidosis Hepatosplenomegaly and Palpable Lymph Nodes Hepatosplenomegaly and palpable lymph nodes may be due to: ¨
Neoplastic Conditions Chronic lymphocytic leukaemia, lymphoma §
Inflammatory Disorders Infectious mononucleosis, sarcoidosis Para-Aortic Lymph Nodes If para-aortic lymph nodes are palpable consider: © Generalised Lymphadenopathy. Para-aortic lymphadenopathy may be part of a generalised lymphadenopathy ª Remember the drainage of the lymph nodes in particular testicular tumours in a male |
ACES for PACES is available on Amazon. It is also available on many other internet bookshops. The link below will take you to amazon .co.uk If you wish to purchase ACES for PACES from your local bookshop, please ask them to order it from wholesalers such as Bertrams or Gardners if they do not have it in stock Search onother websites and from wholesalers using the ISBN number: 1905006047
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